发明申请
- 专利标题: Pyrimidine Derivatives As HSP90 Inhibitors
- 专利标题(中): 嘧啶衍生物作为HSP90抑制剂
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申请号: US11914728申请日: 2006-05-19
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公开(公告)号: US20090215777A1公开(公告)日: 2009-08-27
- 发明人: Gianni Chessari , Miles Stuart Congreve , Owen Callaghan , Suzanna Ruth Cowan , Christopher William Murray , Alison Jo-Anne Woolford , Michael Alistair O'Brien , Andrew James Woodhead
- 申请人: Gianni Chessari , Miles Stuart Congreve , Owen Callaghan , Suzanna Ruth Cowan , Christopher William Murray , Alison Jo-Anne Woolford , Michael Alistair O'Brien , Andrew James Woodhead
- 申请人地址: GB Cambridge
- 专利权人: Astex Therapeutics Ltd.
- 当前专利权人: Astex Therapeutics Ltd.
- 当前专利权人地址: GB Cambridge
- 优先权: GB0510252.0 20050519
- 国际申请: PCT/GB2006/001851 WO 20060519
- 主分类号: A61K31/5377
- IPC分类号: A61K31/5377 ; C07D239/42 ; A61K31/505 ; C07D413/12 ; C07D251/42 ; A61K31/53
摘要:
The invention provides a compound for use as an inhibitor of Hsp90, the compound having the formula (I): or salts, tautomers, solvates or N-oxides thereof; wherein: A is N or a group CR3; R1 is a monocyclic or bicyclic carbocyclic or heterocyclic ring of 5 to 10 ring members of which up to two ring members may be heteroatoms selected from N, O and S and the remainder are carbon atoms, the carbocyclic or heterocyclic ring being optionally substituted by one or more substituent groups independently selected from R10; and R2, R3 and R10 are as defined in the claims.