A biopsy probe includes a body portion, a cannula, a tip, and a cutter. The cannula extends relative to the body portion. The cannula has a first lumen configured to receive a cutter and a transverse aperture configured to receive tissue. The cutter is disposed in the first lumen of the cannula, and is configured to translate relative to the cannula. The tip is located on the distal end of the cannula. An opening is formed through the tip. A second lumen extends through the cannula, and is in fluid communication with the opening formed in the tip. Substances or liquids such as medicine may be dispensed to a biopsy site or other location within the body of a patient via the second lumen and the opening in the tip. The second lumen may be fluidly isolated from the first lumen and any other lumen in the cannula.