A spooled adhesive bandage dispenser includes a case, a replaceable cartridge and an activation wheel. The cartridge is disposed within the case and includes a bandage roll and a waste core. The bandage roll includes a strip of bandage packages sealed between two strips of packaging. The activation wheel is at least partially exposed outside the case. By rotating the activation wheel, the packaging strips are pulled apart and the bandage package is forced out of the case through a slot. At the same time, the packaging strips are wound around the waste core. When the bandage roll is gone, the entire cartridge may be replaced.