发明申请
US20090227788A1 PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES
有权
从氨基 - 氨基苯甲腈制备苯并噻唑的方法
- 专利标题： PROCESS FOR PREPARING BENZOTHIAZEPINES FROM GAMMA-AMINOALKYLBENZENES
- 专利标题（中）： 从氨基 - 氨基苯甲腈制备苯并噻唑的方法
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申请号： US12397212申请日： 2009-03-03
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公开(公告)号： US20090227788A1公开(公告)日： 2009-09-10
- 发明人: Shixian Deng , Sandro Belvedere , Jiaming Yan , Donald Landry
- 申请人： Shixian Deng , Sandro Belvedere , Jiaming Yan , Donald Landry
- 主分类号： C07D417/12
- IPC分类号： C07D417/12 ; C07D281/10
摘要：
The invention provides a process for preparing a 2,3,4,5-tetrahydro[1,4]benzothiazepine of formula: by reacting a [2-(acylaminoethyl)thio]arene of formula with an aldehyde or a multimer thereof, and with an acid. The invention also provides for first reacting the [2-(acylaminoethyl)thio]arene with the aldehyde or multimer thereof and a base to form an [N-hydroxymethyl-2-[acylaminoethyl)thio]arene of formula then treating the [N-hydroxymethyl-2-(acylaminoethyl)thio]arene with the acid to form the 2,3,4,5-tetrahydro[1,4]benzothiazepine.
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