A deodorization material composition, a manufacturing method thereof, and a deodorization method are provided. The deodorization material composition is adapted to eliminate an odor in an environment. The manufacturing method comprises providing nanoscale silver particles, nanoscale calcium particles, a nearly vacuum environment, a preset specific temperature, a medium material, and a post-treatment process, which allows the nanoscale silver particles and the nanoscale calcium particles to be alternately distributed in the medium material and thereby form a stable deodorization material composition. When the deodorization material composition is pressure sprayed into the environment, the nanoscale silver particles and the nanoscale calcium particles collide with or brush air particles to form free positive ions and negative ions respectively, which in turn react with constituents of the odor in the environment to eliminate the odor.