发明申请
US20090233840A1 Modified Dynorphin Expression in Animals and Identification of Compounds for Treatment of Obesity and Diabetes
审中-公开
动物中修饰的Dynorphin表达和用于治疗肥胖和糖尿病的化合物的鉴定
- 专利标题： Modified Dynorphin Expression in Animals and Identification of Compounds for Treatment of Obesity and Diabetes
- 专利标题（中）： 动物中修饰的Dynorphin表达和用于治疗肥胖和糖尿病的化合物的鉴定
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申请号： US11573681申请日： 2005-08-15
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公开(公告)号： US20090233840A1公开(公告)日： 2009-09-17
- 发明人: Herbert Herzog , Amanda Sainsbury-Salis
- 申请人： Herbert Herzog , Amanda Sainsbury-Salis
- 优先权： AU2004904586 20040813
- 国际申请： PCT/AU05/01223 WO 20050815
- 主分类号： A61K38/02
- IPC分类号： A61K38/02 ; A01K67/027 ; C12N15/85 ; G01N33/50 ; C12N5/10 ; C12Q1/68 ; C12N15/63 ; A61P3/04
摘要：
The present invention provides novel transgenic animal models of reduced dynorphin expression in humans that are useful for identifying compounds that are antagonists, inverse agonists, agonists or mimetics of one or more dynorphin peptide products of preprodynorphin. The compounds identified in such screening assays are useful in contexts related to the treatment of obesity and type II diabetes including, for example, improving weight loss and/or reducing appetite during dieting; treating feeding disorders; and for modifying fat mass and reducing glucose intolerance in males.
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