发明申请
- 专利标题: Radioactive Halogen-Labeled Phenyloxyaniline Derivatives
- 专利标题(中): 放射性卤素标记苯氧基苯胺衍生物
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申请号: US11884763申请日: 2005-12-28
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公开(公告)号: US20090234162A1公开(公告)日: 2009-09-17
- 发明人: Kazutoshi Suzuki , Tetsuya Suhara , Christer Halldin , Ming-Rong Zhang , Atsuro Nakazato
- 申请人: Kazutoshi Suzuki , Tetsuya Suhara , Christer Halldin , Ming-Rong Zhang , Atsuro Nakazato
- 申请人地址: JP Toshima-ku JP Chiba-shi
- 专利权人: Taisho Pharmaceutical Co., Ltd.,National Institute of Radiological Sciences
- 当前专利权人: Taisho Pharmaceutical Co., Ltd.,National Institute of Radiological Sciences
- 当前专利权人地址: JP Toshima-ku JP Chiba-shi
- 优先权: JP2005-052527 20050228
- 国际申请: PCT/JP2005/024075 WO 20051228
- 主分类号: C07C233/25
- IPC分类号: C07C233/25
摘要:
A radioactive halogen-labeled phenyoxyaniline derivative represented by the following formula: wherein R1 represents a group such as an alkyl group; X1, X2, X3 and X4 represent each a hydrogen atom, an alkyl group, an alkoxy group, an alkoxy group carrying 11C introduced thereinto or a radioactive halogen atom, provided that at least one of X1, X2, X3 and X4 represents an alkoxy group carrying 11C introduced thereinto or a radioactive halogen atom; which is a compound useful as a PBR ligand having a high affinity and a high selectivity. In in vitro measurement of PBR, a PBR ligand having a high affinity and a high selectivity is labeled with a radioactive halogen nuclear species so as to enable the measurement of PBR in vivo with the use of means including not only PET but also SPECT. Thus, a compound which is useful in early diagnosing, preventing and treating diseases such as Alzheimer type dementia can be obtained.
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