发明申请
- 专利标题: PREVENTIVE/REMEDY FOR ARTERIOSCLEROSIS
- 专利标题(中): 预防/治疗前列腺增生症
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申请号: US12173244申请日: 2008-07-15
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公开(公告)号: US20090239938A1公开(公告)日: 2009-09-24
- 发明人: Takashi KADOWAKI , Toshimasa YAMAUCHI , Naoto KUBOTA , Yasuo TERAUCHI , Tetsuya KUBOTA , Tetsuo NODA , Ryozo NAGAI , Yasushi IMAI
- 申请人: Takashi KADOWAKI , Toshimasa YAMAUCHI , Naoto KUBOTA , Yasuo TERAUCHI , Tetsuya KUBOTA , Tetsuo NODA , Ryozo NAGAI , Yasushi IMAI
- 申请人地址: JP Saitama
- 专利权人: JAPAN SCIENCE AND TECHNOLOGY AGENCY
- 当前专利权人: JAPAN SCIENCE AND TECHNOLOGY AGENCY
- 当前专利权人地址: JP Saitama
- 优先权: JP2002/151220 20020524
- 主分类号: A61K31/7088
- IPC分类号: A61K31/7088
摘要:
A scavenger receptor A expression down-regulator and a drug for preventing or treating arteriosclerosis which contain, as the active ingredient, a C-terminal globular domain of adiponectin, adiponectin, or a gene encoding the domain or adiponectin.According to the present invention, there is provided a preventive or therapeutic agent capable of directly preventing intimal thickening, which constitutes an essential feature of arteriosclerosis. This effect can be attained through arresting the onset and development of arteriosclerosis by reducing the expression level of scavenger receptor A in arterial walls and preventing lipid buildup in macrophages.