发明申请
US20090247548A1 PYRROLOPYRIMIDINE DERIVATIVES FOR TREATING PROLIFERATIVE DISEASES
审中-公开
用于治疗增殖性疾病的吡咯啉衍生物
- 专利标题: PYRROLOPYRIMIDINE DERIVATIVES FOR TREATING PROLIFERATIVE DISEASES
- 专利标题(中): 用于治疗增殖性疾病的吡咯啉衍生物
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申请号: US10597298申请日: 2005-01-28
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公开(公告)号: US20090247548A1公开(公告)日: 2009-10-01
- 发明人: Giorgio Caravatti , Peter Traxler , Thomas Esser , Handan He
- 申请人: Giorgio Caravatti , Peter Traxler , Thomas Esser , Handan He
- 国际申请: PCT/EP2005/000876 WO 20050128
- 主分类号: A61K31/496
- IPC分类号: A61K31/496 ; C07D487/04
摘要:
The present invention relates to a compound of formula I wherein R1 is a heterocyclic radical or an unsubstituted or substituted aromatic radical; G is C1-C7-alkylene, —C(═O)—, or C1-C6-alkylene-C(═O)— wherein the carbonyl group is attached to the piperazine moiety; Q is —NH— or —O—, with the proviso that Q is —O— if G is —C(═O)— or C1-C6-alkylene-C(═O)—; and X is either not present or C1-C7-alkylene, with the proviso that a heterocyclic radical R1 is bonded via a ring carbon atom if X is not present; or a salt thereof, which is useful for treating anti-proliferative diseases.
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