发明申请
- 专利标题: NOVEL COMPOUND WITH AFFINITY FOR AMYLOID
- 专利标题(中): 具有AMYLOID亲和性的新型化合物
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申请号: US12312596申请日: 2007-10-30
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公开(公告)号: US20090252680A1公开(公告)日: 2009-10-08
- 发明人: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- 申请人: Shigeyuki Tanifuji , Daisaku Nakamura , Shinya Takasaki , Yuki Okumura
- 申请人地址: JP Tokyo
- 专利权人: NIHON- MEDI-PHYSICS CO., LTD
- 当前专利权人: NIHON- MEDI-PHYSICS CO., LTD
- 当前专利权人地址: JP Tokyo
- 优先权: JP2006-311203 20061117
- 国际申请: PCT/JP2007/071121 WO 20071030
- 主分类号: A61K51/04
- IPC分类号: A61K51/04 ; C07D471/04 ; A61K101/02
摘要:
A compound represented by the following formula or a salt thereof: wherein each of A1, A2, A3 and A4 independently represents a carbon or nitrogen; R1 is a group selected from the group consisting of hydrogen, hydroxyl group, carboxyl group, sulfuric acid group, amino group, nitro group, cyano group, non-radioactive halogen substituents, alkyl substituents with 1-4 carbon atoms and alkoxy substituents with 1-4 carbon atoms; and R2 is a radioactive halogen substituent, provided at least one of A1, A2, A3 and A4 represents a carbon, and R1 binds to a carbon represented by A1, A2, A3 or A4, is effective as an image diagnosis probe targeting amyloid and as well as a diagnostic agent for Alzheimer's disease including the compound represented by the above formula or a salt thereof.
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