A method for detecting a pressure loss of a tire in a vehicle equipped with a tire pressure monitoring system. The method includes the following steps carried out in the parked state of the vehicle: deactivate the tire pressure monitoring system, which contains at least one electronic wheel device disposed in a vehicle wheel, activate the tire pressure monitoring system after a first defined period of time or upon a vehicle-side request, determine tire-related information of the vehicle wheels associated with the electronic wheel devices by the respective electronic wheel device and generate status signals containing the tire-related information, communicate the status signals to an evaluation device, return to the first method step at the latest after a second period of time.