A method and apparatus of compensating for an asymmetric frequency response of a radio are disclosed. One method includes estimating a slope control signal, the slope control signal indicating a slope of a frequency response of an amplifier chain of the radio. A difference between gain at positive frequencies and gain at negative frequencies of a complex baseband signal is adjusted with the slope control signal, wherein the complex signal includes an I component and a Q component. The adjusted complex baseband signal is frequency up-converted into a radio signal. The radio signal is amplified by the amplifier chain. The amplified radio signal is transmitted.