发明申请
US20090264419A1 CYCLIC MALONAMIDES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
审中-公开
作为Abeta蛋白生产抑制剂的循环马来酸酐
- 专利标题： CYCLIC MALONAMIDES AS INHIBITORS OF Abeta PROTEIN PRODUCTION
- 专利标题（中）： 作为Abeta蛋白生产抑制剂的循环马来酸酐
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申请号： US12433925申请日： 2009-05-01
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公开(公告)号： US20090264419A1公开(公告)日： 2009-10-22
- 发明人: Richard E. Olson , Michael G. Yang
- 申请人： Richard E. Olson , Michael G. Yang
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB PHARMA COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB PHARMA COMPANY
- 当前专利权人地址： US NJ Princeton
- 主分类号： A61K31/5513
- IPC分类号： A61K31/5513 ; C07D243/24 ; A61P25/28 ; A61P25/00
摘要：
This invention relates to novel cyclic malonamides having the formula (I): to their pharmaceutical compositions and to their methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.