发明申请
- 专利标题: Multifunctional biomaterials as scaffolds for electronic, optical, magnetic, semiconducting, and biotechnological applications
- 专利标题(中): 多功能生物材料作为电子,光学,磁性,半导体和生物技术应用的支架
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申请号: US12367824申请日: 2009-02-09
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公开(公告)号: US20090269619A1公开(公告)日: 2009-10-29
- 发明人: Angela M. BELCHER , Beau R. Peelle , Ki Tae Nam
- 申请人: Angela M. BELCHER , Beau R. Peelle , Ki Tae Nam
- 专利权人: Board to Regents, The University of Texas System,Massachusetts Institute of Technology
- 当前专利权人: Board to Regents, The University of Texas System,Massachusetts Institute of Technology
- 主分类号: H01M8/16
- IPC分类号: H01M8/16 ; C12N7/00 ; C40B50/06 ; C40B40/02
摘要:
One-dimensional ring structures from M13 viruses were constructed by two genetic modifications encoding binding peptides and synthesis of a heterobifunctional linker molecule. The bifunctional viruses displayed an anti-streptavidin peptide and hexahistidine (SEQ ID NO:4) peptide at opposite ends of the virus as pIII and pIX fusions. Stoichiometric addition of the streptavidin-NiNTA linker molecule led to the reversible formation of virus-based nanorings with circumferences corresponding to lengths of the packageable DNAs. These virus-based ring structures can be further engineered to nucleate inorganic materials and form metallic, magnetic, or semiconductor nanorings using trifunctionalized viruses.