Invention Application
- Patent Title: Pyrimidinyl pyridone inhibitors of kinases
- Patent Title (中): 嘧啶嘧啶激酶抑制剂
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Application No.: US12387181Application Date: 2009-04-29
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Publication No.: US20090270389A1Publication Date: 2009-10-29
- Inventor: Frederick Brookfield , Florence Eustache , Michael Patrick Dillon , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Jaehyeon Park , Deborah Carol Reuter , Eric Brian Sjogren
- Applicant: Frederick Brookfield , Florence Eustache , Michael Patrick Dillon , David Michael Goldstein , Leyi Gong , Xiaochun Han , Joan Heather Hogg , Jaehyeon Park , Deborah Carol Reuter , Eric Brian Sjogren
- Assignee: Roche Palo Alto LLC
- Current Assignee: Roche Palo Alto LLC
- Main IPC: A61K31/5377
- IPC: A61K31/5377 ; C07D471/04 ; A61K31/519 ; A61P35/00

Abstract:
This application discloses novel pyrimidinyl pyridone derivatives according to formula I, wherein A, R1, R2, R3, and m are defined as described herein, which inhibit JNK. The compounds disclosed herein are useful to modulate the activity of JNK and treat diseases associated with excessive JNK activity. The compounds are useful to treat autoimmune, inflammatory, metabolic, and neurological diseases as well as cancer. Also disclosed are compositions comprising the compound of formula I and methods of treatment comprising administering a therapeutically effective amount of the compound of formula I to a subject in need thereof.
Public/Granted literature
- US08268840B2 Pyrimidinyl pyridone inhibitors of kinases Public/Granted day:2012-09-18
Information query
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