发明申请
US20090280483A1 Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors
审中-公开
筛选白细胞介素-6（IL-6）信号转导抑制剂的方法
- 专利标题： Methods for Screening Interleukin-6 (IL-6) Signal Transduction Inhibitors
- 专利标题（中）： 筛选白细胞介素-6（IL-6）信号转导抑制剂的方法
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申请号： US12085324申请日： 2005-11-22
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公开(公告)号： US20090280483A1公开(公告)日： 2009-11-12
- 发明人: Toshio Kitamura , Toshiyuki Kawashima
- 申请人： Toshio Kitamura , Toshiyuki Kawashima
- 国际申请： PCT/JP2005/021485 WO 20051122
- 主分类号： C12Q1/02
- IPC分类号： C12Q1/02 ; C12Q1/68 ; C12Q1/48 ; C07C49/255 ; C07C49/213 ; C07C215/20 ; C07C275/28 ; C07D333/68 ; C07D277/38
摘要：
The present invention provides methods for screening compounds which inhibit activation of a member of the IL-6 signaling pathways, comprising: (a) a positive screening step using a cell capable of being killed by IL-6 stimulation to select compounds which inhibit death of the cell when it is stimulated by IL-6; and then (b) a biochemical screening step to further select compounds which inhibit activation of a member of the IL-6 signaling pathways by a biochemical means from the compounds selected in step (a). The present invention also provides compounds which inhibit activation of a member of the IL-6 signaling pathways identified using said methods.