发明申请
US20090281139A1 MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS
审中-公开
大环因子VIIA抑制剂作为抗凝剂有用
- 专利标题： MACROCYCLIC FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS
- 专利标题（中）： 大环因子VIIA抑制剂作为抗凝剂有用
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申请号： US12507907申请日： 2009-07-23
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公开(公告)号： US20090281139A1公开(公告)日： 2009-11-12
- 发明人: Eldon Scott Priestley , Daniel L. Cheney , Nicolas Ronald Wurtz , Peter W. Glunz
- 申请人： Eldon Scott Priestley , Daniel L. Cheney , Nicolas Ronald Wurtz , Peter W. Glunz
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 主分类号： A61K31/4725
- IPC分类号： A61K31/4725 ; C07D245/00 ; A61P7/02
摘要：
The present invention relates generally to novel macrocycles of Formula (I): or stereoisomers, tautomers, pharmaceutically acceptable salts, solvates, or prodrugs thereof, wherein the variables A, B, L, M, W, Z, R1, R2, R3, R4, R5, R6, R7, R8, R9, and R10 are as defined herein. These compounds are selective inhibitors of the serine protease coagulation factor VIIa which can be used as medicaments.