A computing device, method and computer program product provide for dynamically activating a domain specific plug-in for operation with a Web browser. A mapping is defined that provides an association between the plug-in and at least part of each website with which the plug-in is to operate, with the mapping comprising a respective domain name for each website. The plug-in is activated for operation, in accordance with the mapping, only when a current domain that is active with the Web browser is associated with the plug-in. The mapping may comprise a domain filter comprising a URL expression. Plug-ins that are domain specific may be made accessible only when a user is actively using the domain, allowing the user to use one or more plug-ins simultaneously without unnecessarily sacrificing screen space and/or bandwidth used by the plug-in.