An apparatus and a method for transiting an operation mode of a femto base station in a wireless communication system are provided. The method includes, in a sleep mode, confirming whether operation transition request information is received from at least one terminal; and when receiving the operation transition request information from the terminal, entering an active mode. Thus, the power consumption of the femto base station can be reduced and the interference caused by the operation of the femto base station can be mitigated.