发明申请
US20090286777A1 5,6,Fused Pyrrolidine Compounds Useful as Tachykinin Receptor Antagonists
审中-公开
5,6，用作速激肽受体拮抗剂的熔融吡咯烷化合物
- 专利标题： 5,6,Fused Pyrrolidine Compounds Useful as Tachykinin Receptor Antagonists
- 专利标题（中）： 5,6，用作速激肽受体拮抗剂的熔融吡咯烷化合物
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申请号： US12226294申请日： 2007-05-11
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公开(公告)号： US20090286777A1公开(公告)日： 2009-11-19
- 发明人: Jianming Bao , Robert J. DeVita , Sander G. Mills , Gregori J. Morriello
- 申请人： Jianming Bao , Robert J. DeVita , Sander G. Mills , Gregori J. Morriello
- 国际申请： PCT/US07/11367 WO 20070511
- 主分类号： A61K31/437
- IPC分类号： A61K31/437 ; C07D471/04 ; A61K31/5377 ; A61K31/506
摘要：
The present invention is directed to certain 5,6-fused pyrrolidine compounds which are useful as neurokinin-1 (NK-1) receptor antagonists, and inhibitors of tachykinin and in particular substance P. The invention is also concerned with pharmaceutical formulations comprising these compounds as active ingredients and the use of the compounds and their formulations in the treatment of certain disorders, including emesis, urinary incontinence, depression, and anxiety.
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