发明申请
- 专利标题: Chromane Derivatives Useful As Acid Pump Antagonists
- 专利标题(中): 色氨酸衍生物可用作酸泵拮抗剂
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申请号: US11721453申请日: 2005-12-07
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公开(公告)号: US20090291977A1公开(公告)日: 2009-11-26
- 发明人: Madoka Jinno , Hirohisa Shimokawa , Tatsuya Yamagishi
- 申请人: Madoka Jinno , Hirohisa Shimokawa , Tatsuya Yamagishi
- 国际申请: PCT/IB05/03758 WO 20051207
- 主分类号: A61K31/437
- IPC分类号: A61K31/437 ; C07D471/04
摘要:
This invention relates to compounds of the formula (I): or a pharmaceutically acceptable salt thereof, wherein: R′, R2, R3, R4, R5, R6, R7, R8 A and B are each as described herein or a pharmaceutically acceptable salt, and compositions containing such compounds and the method of treatment and the use, comprising such compounds for the treatment of a condition mediated by acid pump antagonistic activity such as, but not limited to, as gastrointestinal disease, gastroesophageal disease, gastroesophageal reflux disease (GERD), peptic ulcer, gastric ulcer, duodenal ulcer, NSAID-induced ulcers, gastritis, infection of Helicobacter pylori, dyspepsia, functional dyspepsia, Zollinger-Ellison syndrome, non-crosive reflux disease (NERD), visceral pain, heartburn, nausea, esophagitis, dysphagia, hypersalivation, airway disorders or asthma.
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