发明申请
- 专利标题: 5-Lipoxygenase-Activating Protein Inhibitor
- 专利标题(中): 5-脂氧合酶活化蛋白抑制剂
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申请号: US12471106申请日: 2009-05-22
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公开(公告)号: US20090291981A1公开(公告)日: 2009-11-26
- 发明人: Kevin Murray SCHAAB , Christopher David KING , Nicholas Simon STOCK
- 申请人: Kevin Murray SCHAAB , Christopher David KING , Nicholas Simon STOCK
- 申请人地址: US CA San Diego
- 专利权人: AMIRA PHARMACEUTICALS, INC.
- 当前专利权人: AMIRA PHARMACEUTICALS, INC.
- 当前专利权人地址: US CA San Diego
- 主分类号: A61K31/444
- IPC分类号: A61K31/444 ; C07D401/14 ; A61P11/06
摘要:
Described herein is the FLAP inhibitor 3-[3-tert-butylsulfanyl-1-[4-(6-ethoxy-pyridin-3-yl)-benzyl]-5-(5-methyl-pyridin-2-ylmethoxy)-1H-indol-2-yl]-2,2-dimethyl-propionic acid, or a pharmaceutically acceptable salt thereof. Also described are methods of preparing the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, including solvates, and polymorphs thereof. Also described herein are pharmaceutical compositions suitable for administration to a mammal that include the FLAP inhibitor, or a pharmaceutically acceptable salt thereof, and methods of using such pharmaceutical compositions for treating respiratory conditions or diseases, as well as other leukotriene-dependent or leukotriene mediated conditions or diseases.
公开/授权文献
- US08772495B2 5-lipoxygenase-activating protein inhibitor 公开/授权日:2014-07-08
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