发明申请
- 专利标题: GROWTH FACTORS FOR PRODUCTION OF DEFINITIVE ENDODERM
- 专利标题(中): 生长限定因子的生长因子
-
申请号: US12132437申请日: 2008-06-03
-
公开(公告)号: US20090298178A1公开(公告)日: 2009-12-03
- 发明人: Kevin Allen D'Amour
- 申请人: Kevin Allen D'Amour
- 主分类号: C12N5/06
- IPC分类号: C12N5/06
摘要:
Disclosed herein are methods for generating endoderm lineage type cells derived from human pluripotent cells, such as human embryonic stem cells, by using various agents including, but not limited to, GDF8, GDF11 and GSK-3beta inhibitors. Also disclosed herein are endoderm lineage cell populations or compositions, such as populations or compositions comprising definitive endoderm and/or other definitive endoderm-derived cell types.