发明申请
- 专利标题: OXIME COMPOUNDS AND THE USE THEREOF
- 专利标题(中): OXIME化合物及其用途
-
申请号: US12373328申请日: 2007-07-12
-
公开(公告)号: US20090298878A1公开(公告)日: 2009-12-03
- 发明人: Akira Matsumura , Hidenori Mikamiyama , Naoki Tsuno , Donald J. Kyle , Bin Shao , Jiangchao Yao
- 申请人: Akira Matsumura , Hidenori Mikamiyama , Naoki Tsuno , Donald J. Kyle , Bin Shao , Jiangchao Yao
- 国际申请: PCT/US07/15827 WO 20070712
- 主分类号: A61K31/445
- IPC分类号: A61K31/445 ; C07D211/98 ; G01N23/00 ; C07D401/12
摘要:
The invention relates to oxime compounds of Formula (I) and pharmaceutically acceptable salts, prodrugs, or solvates thereof, wherein X is hydrogen, optionally substituted aryl, optionally substituted heteroaryl or the like; Y is CO, SO2, CR3R4 or the like; Z is optionally substituted lower alkyl, optionally substituted aryl or the like; W is optionally substituted lower alkylene or optionally substituted lower alkenylene, R3 and R4 are each independently hydrogen, lower alkyl or the like; p is 0, 1, or 2 and q is 0, 1 or 2. The invention is also directed to the use compounds of Formula I to treat, prevent or ameliorate a disorder responsive to the blockade of calcium channels, and particularly N-type calcium channels. Compounds of the present invention are especially useful for treating pain.