发明申请
US20090304727A1 HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO THE LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN THE TREATMENT OF ALLERGIES
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超临界二氧化碳蛋白质与巴西利亚的脂肪转运家族JUDAICA用于治疗过敏症
- 专利标题： HYPOALLERGENIC CHIMERIC PROTEINS BELONGING TO THE LIPID TRANSFER FAMILY OF PARIETARIA JUDAICA FOR USE IN THE TREATMENT OF ALLERGIES
- 专利标题（中）： 超临界二氧化碳蛋白质与巴西利亚的脂肪转运家族JUDAICA用于治疗过敏症
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申请号： US12296260申请日： 2007-04-11
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公开(公告)号： US20090304727A1公开(公告)日： 2009-12-10
- 发明人: Juan Andres Asturias Ortega , Alberto Martinez Garate , Roberto Gonzales Rioja
- 申请人： Juan Andres Asturias Ortega , Alberto Martinez Garate , Roberto Gonzales Rioja
- 申请人地址： ES BILBAO
- 专利权人： BIAL INDUSTRIAL FARMACEUTICA, S.A.
- 当前专利权人： BIAL INDUSTRIAL FARMACEUTICA, S.A.
- 当前专利权人地址： ES BILBAO
- 优先权： ES200600955 20060412
- 国际申请： PCT/IB2007/001025 WO 20070411
- 主分类号： A61K39/00
- IPC分类号： A61K39/00 ; C07K14/00 ; C12N15/11 ; C12N1/21 ; C12P21/02 ; A61P37/08
摘要：
The present invention relates to recombinant DNA molecules which encode chimeric polypeptides of differing allergens of Parietaria judaica which can be used for the prevention and treatment of allergies, in particular pollen allergies. Specifically, chimeric polypeptides composed of fragments of the allergens Par j 1 and Par j 2 having hypoallergenic characteristics are described. Methods for producing these recombinant polypeptides in heterologous expression systems are also described. Efficient methods of purifying the chimeric proteins are also described.
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