The interdental cleaner includes a source of liquid (22) and a control system (42) including a manual pump (26), for moving a selected amount of liquid, suitable for a single use, into a liquid pathway and there to a mixing chamber (53). A source of pressurized gas (30), such as a CO2 cartridge, is used to preload a selected amount of gas into a gas chamber (52). The control system includes a spring-loaded button (18), which upon operation results in the manual pump (26) being operated, forcing the selected amount of liquid into the mixing chamber, and then upon release, permits the pressurized gas in the gas chamber to enter the mixing chamber, breaking up the liquid therein into droplets and a liquid stream, and propelling the resulting liquid out of a nozzle portion (14) of the cleaner into the interproximal area of the teeth.