发明申请
- 专利标题： COMPOUNDS CAPABLE OF AFFECTING DIFFERENTIATION, PROLIFERATION, REGENERATION, PLASTICITY AND SURVIVAL CELLS
- 专利标题（中）： 影响分化，增殖，再生，塑性和存活细胞的化合物
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申请号： US12435043申请日： 2009-05-04
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公开(公告)号： US20090305951A1公开(公告)日： 2009-12-10
- 发明人: Vladislav V. Kiselyov , Galina Skladchikova , Vladimir Berezin , Elisabeth Bock
- 申请人： Vladislav V. Kiselyov , Galina Skladchikova , Vladimir Berezin , Elisabeth Bock
- 优先权： DKPA200101228 20010817; DKPA200200667 20020502
- 主分类号： A61K38/18
- IPC分类号： A61K38/18 ; C07K14/47 ; A61K38/16 ; A61P17/02
摘要：
The present invention relates to a compound comprising the third Immunoglobulin (Ig3) module, and/or the fourth Immunoglobulin (Ig4) module, and/or the fifth immunoglobulin (Ig5) module, and/or the first Fibronectin III (Fn3,1) module, and/or the second Fibronectin III (Fn3,2) module of neural cell adhesion molecule (NCAM), or a fragment, or a variant thereof, capable of interacting with an Fibroblast Growth Factor (FGF) receptor and/or Adenosine-Tri-Phosphate (ATP) and/or L1, and thereby the compounds are capable of inducing differentiation, modulating proliferation, stimulate regeneration, neuronal plasticity and/or survival of cells. Further, the present invention relates to a pharmaceutical composition comprising said compound, a process of producing a pharmaceutical composition and the use of said compound.
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