发明申请
US20090306090A1 HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS
失效
杂环衍生物及其作为硬脂酸脱乙酰酶抑制剂的用途
- 专利标题： HETEROCYCLIC DERIVATIVES AND THEIR USE AS STEAROYL-COA DESATURASE INHIBITORS
- 专利标题（中）： 杂环衍生物及其作为硬脂酸脱乙酰酶抑制剂的用途
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申请号： US12541005申请日： 2009-08-13
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公开(公告)号： US20090306090A1公开(公告)日： 2009-12-10
- 发明人: Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vandna Raina , Serguei Sviridov , Vishnumurthy Kodumuru , Nagasree Chakka , Shifeng Lui , Shaoyi Sun , Duanjie Hou
- 申请人： Rajender Kamboj , Zaihui Zhang , Jianmin Fu , Vandna Raina , Serguei Sviridov , Vishnumurthy Kodumuru , Nagasree Chakka , Shifeng Lui , Shaoyi Sun , Duanjie Hou
- 申请人地址： CA Burnaby
- 专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人： Xenon Pharmaceuticals Inc.
- 当前专利权人地址： CA Burnaby
- 主分类号： A61K31/501
- IPC分类号： A61K31/501 ; C12N9/99 ; C07D403/04
摘要：
Methods of treating an SCD-mediated disease or condition in a mammal, preferably a human, are disclosed, wherein the methods comprise administering to a mammal in need thereof a compound of formula (I): where x, y, G, J, K, L, M, W, R2, R3, R5, R5a, R6, R6a, R7, R7a, R8 and R8a are defined herein. Pharmaceutical compositions comprising the compounds of formula (I) are also disclosed.
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