Various systems and methods are described for controlling engine operation of an engine having a plurality of cylinders, each cylinder including a first and second injector for delivering fuel to the cylinder. One example method comprises operating a first cylinder to combust fuel delivered from both the first and second fuel injector of the first cylinder, and operating a second cylinder to combust fuel delivered from only one of the first and second fuel injectors of the second cylinder. One example system comprises both a port injector and a direct injector coupled to both of a first and second cylinder of the engine with a first fuel reservoir coupled to the port injectors and a second fuel reservoir coupled to the direct injectors. The system further includes a controller configured to vary delivery of the fuels from the injectors to the cylinders during differing operating modes.