发明申请
US20090311181A1 Engineered Anti-Prostate Stem Cell Antigen (PSCA) Antibodies for Cancer Targeting
有权
用于癌症靶向的工程化抗前列腺干细胞抗原（PSCA）抗体
- 专利标题： Engineered Anti-Prostate Stem Cell Antigen (PSCA) Antibodies for Cancer Targeting
- 专利标题（中）： 用于癌症靶向的工程化抗前列腺干细胞抗原（PSCA）抗体
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申请号： US12293860申请日： 2007-03-20
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公开(公告)号： US20090311181A1公开(公告)日： 2009-12-17
- 发明人: Anna M. Wu , Robert E. Reiter
- 申请人： Anna M. Wu , Robert E. Reiter
- 申请人地址： US CA Oakland
- 专利权人： The Regents of the University of California
- 当前专利权人： The Regents of the University of California
- 当前专利权人地址： US CA Oakland
- 国际申请： PCT/US2007/007020 WO 20070320
- 主分类号： A61K49/00
- IPC分类号： A61K49/00 ; C07K16/30 ; A61K49/04 ; G01N33/574 ; A61K39/395
摘要：
The invention provides novel humanized antibody fragments that specifically bind prostate cell-surface antigen (PSCA), a protein which is overexpressed in variety of cancers, including prostate, bladder, and pancreatic cancer. Methods are provided for the use of the compositions of the invention for the treatment of cancer, diagnosis of cancer, to provide a prognosis of cancer progression, and for cancer imaging.
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