发明申请
- 专利标题： EXPRESSION OF O-GLYCOSYLATED THERAPEUTIC PROTEINS IN PROKARYOTIC MICROORGANISMS
- 专利标题（中）： 原核微生物中O-糖苷化治疗蛋白的表达
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申请号： US12297488申请日： 2007-04-19
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公开(公告)号： US20090311744A1公开(公告)日： 2009-12-17
- 发明人: Shawn DeFrees , Marc F. Schwartz , Karl Johnson
- 申请人： Shawn DeFrees , Marc F. Schwartz , Karl Johnson
- 国际申请： PCT/US07/09782 WO 20070419
- 主分类号： C12P21/06
- IPC分类号： C12P21/06 ; C12N1/21
摘要：
The invention relates to methods of producing an O-glycosylated soluble therapeutic protein in a prokaryotic microorganism by co-expressing the therapeutic protein and a heterologous glycosyltransferase that transfers a sugar moiety to an amino acid acceptor on the therapeutic protein.
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