发明申请
US20090312308A1 COMPOUNDS AND COMPOSITIONS AS HEDGEHOG SIGNALING PATHWAY MODULATORS
失效
化合物和组合物作为HEDGEHOG信号路径调制器
- 专利标题： COMPOUNDS AND COMPOSITIONS AS HEDGEHOG SIGNALING PATHWAY MODULATORS
- 专利标题（中）： 化合物和组合物作为HEDGEHOG信号路径调制器
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申请号： US12374739申请日： 2007-07-24
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公开(公告)号： US20090312308A1公开(公告)日： 2009-12-17
- 发明人: Dai Cheng , Dong Han , Wenqi Gao , Jiqing Jiang , Shifeng Pan , Yongqin Wan , Qihui Jin
- 申请人： Dai Cheng , Dong Han , Wenqi Gao , Jiqing Jiang , Shifeng Pan , Yongqin Wan , Qihui Jin
- 申请人地址： BM HAMILTON
- 专利权人： IRM LLC
- 当前专利权人： IRM LLC
- 当前专利权人地址： BM HAMILTON
- 国际申请： PCT/US07/74268 WO 20070724
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D413/14 ; C07D413/12 ; C07D233/64 ; C07D401/14 ; C07D417/14 ; C12N5/00 ; A61K31/4164 ; A61K31/4725 ; A61K31/55 ; A61K31/4545 ; A61K31/541 ; A61P35/00
摘要：
The invention provides a method for modulating the activity of the hedgehog signaling pathway. In particular, the invention provides a method for inhibiting aberrant growth states resulting from phenotypes such as Ptc loss-of-function, hedgehog gain-of-function, smoothened gain-of-function or Gli gain-of-function, comprising contacting a cell with a sufficient amount of a compound of Formula I.