发明申请
US20090312544A1 METHOD FOR PREPARING LAMORTRIGINE AND ITS INTERMEDIATE 2,3-DICHLOROBENZOYL CHLORIDE
审中-公开
制备LAMORTRIGINE及其中间体2,3-二氯苯甲酰氯的方法
- 专利标题： METHOD FOR PREPARING LAMORTRIGINE AND ITS INTERMEDIATE 2,3-DICHLOROBENZOYL CHLORIDE
- 专利标题（中）： 制备LAMORTRIGINE及其中间体2,3-二氯苯甲酰氯的方法
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申请号： US12301747申请日： 2007-05-30
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公开(公告)号： US20090312544A1公开(公告)日： 2009-12-17
- 发明人: Dirk Van Deynse , Marc Belmans , Frank Boers , Michel Dumur , Alain Laconi
- 申请人： Dirk Van Deynse , Marc Belmans , Frank Boers , Michel Dumur , Alain Laconi
- 申请人地址： FR Calais Cedex
- 专利权人： Calaire Chimie SAS
- 当前专利权人： Calaire Chimie SAS
- 当前专利权人地址： FR Calais Cedex
- 优先权： EP06290888.4 20060531
- 国际申请： PCT/EP2007/055251 WO 20070530
- 主分类号： C07D253/075
- IPC分类号： C07D253/075
摘要：
A method for preparing 3,5-diamino-6-(2,3-dichlorophenyl)-1,2,4-triazine, commonly known as lamotrigine, is disclosed. A method of preparing the intermediate, 2,3-dichlorobenzoyl chloride, by photochlorination of 2,3-dichlorobenzotrichloride followed by hydrolysis is also disclosed. The intermediate may then be used in the preparation of lamotrigine.
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