发明申请
US20090317359A1 2,6-DISUBSTITUTED QUINAZOLINES, QUINOXALINES, QUINOLINES AND ISOQUINOLINES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
审中-公开
2,6-取代的喹唑啉，喹喔啉，喹啉和异喹啉及其作为RAF激酶抑制剂的方法
- 专利标题： 2,6-DISUBSTITUTED QUINAZOLINES, QUINOXALINES, QUINOLINES AND ISOQUINOLINES AND METHODS OF THEIR USE AS INHIBITORS OF RAF KINASE
- 专利标题（中）： 2,6-取代的喹唑啉，喹喔啉，喹啉和异喹啉及其作为RAF激酶抑制剂的方法
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申请号： US12554748申请日： 2009-09-04
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公开(公告)号： US20090317359A1公开(公告)日： 2009-12-24
- 发明人: Savithri Ramurthy , Paul A. Renhowe , Sharadha Subramanian
- 申请人： Savithri Ramurthy , Paul A. Renhowe , Sharadha Subramanian
- 申请人地址： US CA Emeryville
- 专利权人： NOVARTIS VACCINES AND DIAGNOSTICS INC.
- 当前专利权人： NOVARTIS VACCINES AND DIAGNOSTICS INC.
- 当前专利权人地址： US CA Emeryville
- 主分类号： A61K38/20
- IPC分类号： A61K38/20 ; A61K31/517 ; A61K33/24 ; A61K31/506 ; A61K31/704 ; A61K39/395 ; A61K31/7068 ; A61K31/5377 ; A61P35/00
摘要：
New substituted quinazoline, quinoxaline, quinoline and isoquinoline compounds, compositions and methods of inhibition of Raf kinase activity in a human or animal subject are provided. The new compounds compositions may be used either alone or in combination with at least one additional agent for the treatment of a Raf kinase mediated disorder, such as cancer.