Embodiments addressing MAC processing for efficient use of high throughput systems are disclosed. Data associated with at least one MAC ID can be aggregated into a single byte stream. The single byte stream can be formatted into MAC PDUs and then muxed. The muxed MAC PDUs can then be transmitted on a single MAC frame. Muxing of the MAC PDUs can be based on the priority of the MAC PDUs or other criteria. A MAC header can comprise information about the muxed PDUs, such as a pointer, that identifies the location of the MAC PDUs within the MAC frame. A MAC frame can contain partial MAC PDUs. The transmitted muxed MAC PDUs can be retransmitted, and an acknowledgment or feedback scheme may be used to help manage the transmission of the protocol data units.