发明申请
- 专利标题: INDAZOLYL DERIVATIVES USEFUL AS POTASSIUM CHANNEL MODULATING AGENTS
- 专利标题(中): 有用的盐酸衍生物作为钾通道调节剂
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申请号: US12444344申请日: 2007-10-03
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公开(公告)号: US20090325989A1公开(公告)日: 2009-12-31
- 发明人: Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
- 申请人: Birgitte L. Eriksen , Ulrik Svane Sorensen , Charlotte Hougaard , Lene Teuber , Dan Peters , Palle Christophersen , Tina Holm Johansen
- 申请人地址: DK BALLERUP
- 专利权人: NEUROSEARCH A/S
- 当前专利权人: NEUROSEARCH A/S
- 当前专利权人地址: DK BALLERUP
- 优先权: DKPA2006-01280 20061003
- 国际申请: PCT/EP07/60493 WO 20071003
- 主分类号: A61K31/506
- IPC分类号: A61K31/506 ; C07D401/04 ; A61P9/10
摘要:
This invention relates to novel indazolyl derivatives useful as potassium channel modulating agents, and their use in the preparation of pharmaceutical compositions.Moreover the invention is directed to pharmaceutical compositions useful for the treatment or alleviation of diseases or disorders associated with the activity of potassium channels, in particular respiratory diseases, epilepsy, convulsions, seizures, absence seizures, vascular spasms, coronary artery spasms, renal disorders, polycystic kidney disease, bladder spasms, urinary incontinence, bladder outflow obstruction, erectile dysfunction, gastrointestinal dysfunction, secretory diarrhoea, ischaemia, cerebral ischaemia, ischaemic heart disease, angina pectoris, coronary heart disease, autism, ataxia, traumatic brain injury, Parkinson's disease, bipolar disorder, psychosis, schizophrenia, anxiety, depression, mania, mood disorders, dementia, memory and attention deficits, Alzheimer's disease, amyotrophic lateral sclerosis (ALS), dysmenorrhea, narcolepsy, Reynaud's disease, intermittent claudication, Sjorgren's syndrome, arrhythmia, hypertension, myotonic muscle dystrophia, spasticity, xerostomi, diabetes type II, hyperinsulinemia, premature labour, baldness, cancer, irritable bowel syndrome, immune suppression, migraine and pain.