发明申请
- 专利标题： SASPASE KNOCKOUT ANIMAL
- 专利标题（中）： SASPASE KNOCKOUT动物
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申请号： US12088640申请日： 2006-10-04
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公开(公告)号： US20100005534A1公开(公告)日： 2010-01-07
- 发明人: Takeshi Matsui , Fumie Kisumi
- 申请人： Takeshi Matsui , Fumie Kisumi
- 申请人地址： JP Bunkyo-ku, Tokyo
- 专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人： Eisai R&D Management Co., Ltd.
- 当前专利权人地址： JP Bunkyo-ku, Tokyo
- 优先权： JP2005-296611 20051011
- 国际申请： PCT/JP2006/319834 WO 20061004
- 主分类号： A01K67/00
- IPC分类号： A01K67/00 ; A01K67/027
摘要：
Knockout animals in which a gene encoding a SASPase has been deleted (hereinafter, referred to as SASPase KO animals) are provided. The SASPase KO animals deficient in expression of functional SASPase were produced by deleting a gene encoding a stratified epithelium-specific protease, SASPase, through targeted disruption. The SASPase KO animals showed a significant increase in wrinkles on the sides of the body and so on. The SASPase KO animals find utility as animal models of wrinkles.
公开/授权文献
- US07834238B2 Saspase knockout animal 公开/授权日：2010-11-16