发明申请
US20100009966A1 SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION
审中-公开
作为ABETA蛋白质生产的抑制剂的替代的LACTAMS
- 专利标题： SUBSTITUTED LACTAMS AS INHIBITORS OF ABETA PROTEIN PRODUCTION
- 专利标题（中）： 作为ABETA蛋白质生产的抑制剂的替代的LACTAMS
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申请号： US12560213申请日： 2009-09-15
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公开(公告)号： US20100009966A1公开(公告)日： 2010-01-14
- 发明人: Qi HAN , Hong Liu , Richard E. Olson , Michael G. Yang
- 申请人： Qi HAN , Hong Liu , Richard E. Olson , Michael G. Yang
- 申请人地址： US NJ Princeton
- 专利权人： BRISTOL-MYERS SQUIBB PHARMA COMPANY
- 当前专利权人： BRISTOL-MYERS SQUIBB PHARMA COMPANY
- 当前专利权人地址： US NJ Princeton
- 主分类号： A61K31/55
- IPC分类号： A61K31/55 ; C07D243/24 ; A61K31/5513 ; C07D223/14 ; A61P43/00
摘要：
This invention relates to novel lactams of Formula (I): having drug and bio-affecting properties, their pharmaceutical compositions and methods of use. These novel compounds inhibit the processing of amyloid precursor protein and, more specifically, inhibit the production of Aβ-peptide, thereby acting to prevent the formation of neurological deposits of amyloid protein. More particularly, the present invention relates to the treatment of neurological disorders related to β-amyloid production such as Alzheimer's disease and Down's Syndrome.
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