发明申请
- 专利标题： HIV INHIBITING 6-SUBSTITUTED PYRIMIDINES
- 专利标题（中）： 艾滋病毒抑制6-取代的吡咯烷酮
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申请号： US12521189申请日： 2007-12-28
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公开(公告)号： US20100016317A1公开(公告)日： 2010-01-21
- 发明人: Jerôme Emile Georges Guillemont , Celine Isabelle Mordant
- 申请人： Jerôme Emile Georges Guillemont , Celine Isabelle Mordant
- 优先权： EP06127325.6 20061229
- 国际申请： PCT/EP07/64605 WO 20071228
- 主分类号： A61K31/5377
- IPC分类号： A61K31/5377 ; C07D239/02 ; A61K31/505 ; C07D413/00
摘要：
HIV replication inhibitors of formula R1 is hydrogen; aryl; formyl; C1-6alkylcarbonyl; C1-6alkyl; C1-6alkyloxycarbonyl; R2, R3, R6 and R7 are hydrogen; hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy; carboxyl; C1-6alkyloxycarbonyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; —C(═O)R9; optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl; R4 and R5 are hydroxy; halo; C3-7cycloalkyl; C1-6alkyloxy; carboxyl; C1-6alkyloxycarbonyl; formyl; cyano; nitro; amino; mono- or di(C1-6alkyl)amino; polyhaloC1-6alkyl; polyhaloC1-6alkyloxy; —C(═O)R9; cyano; —S(═O)rR9; —NH—S(═O)2R9; —NHC(═O)H; —C(═O)NHNH2; —NHC(═O)R9; Het; —Y-Het; optionally substituted C1-6alkyl, C2-6alkenyl or C2-6alkynyl; R5 is pyridyl, —C(═O)NR5aR5b; —CH(OR5c)R5d; —CH2—NR5eR5f; —CH═NOR5a; —CH2—O—C2-6alkenyl; —CH2—O—P(═O)(OR5g)2; —CH2—O—C(═O)—NH2; —C(═O)—R5d; X is —NR1—, —O—, —CH2—, —S—; pharmaceutical compositions containing these compounds as active ingredient and processes for preparing said compounds and compositions.
公开/授权文献
- US09006243B2 HIV inhibiting 6-substituted pyrimidines 公开/授权日：2015-04-14
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