发明申请
US20100016375A1 1,5-DIPHENYL-3-PYRIDINYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATOR
失效
作为CB1受体调节剂的1,5-二苯基-3-吡啶基亚胺-1,5-二氢吡咯烷-2-酮
- 专利标题： 1,5-DIPHENYL-3-PYRIDINYLAMINO-1,5-DIHYDROPYRROLIDIN-2-ONE AS CB1 RECEPTOR MODULATOR
- 专利标题（中）： 作为CB1受体调节剂的1,5-二苯基-3-吡啶基亚胺-1,5-二氢吡咯烷-2-酮
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申请号： US12444692申请日： 2007-10-22
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公开(公告)号： US20100016375A1公开(公告)日： 2010-01-21
- 发明人: John Mehnert Schaus , Perry Clark Heath
- 申请人： John Mehnert Schaus , Perry Clark Heath
- 国际申请： PCT/US07/82041 WO 20071022
- 主分类号： A61K31/4439
- IPC分类号： A61K31/4439 ; C07D401/12 ; C07D207/36 ; A61P3/04
摘要：
Compound and pharmaceutical compositions of Formula by blockade of the CB1 receptors via an inverse agonism mechanism, and are useful for reducing body weight in mammals, cognitive impairment associated with schizophrenia, mitigating treatment emergent weight gain observed during treatment with antipsychotics and have increased bioavailability.
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