发明申请
- 专利标题： HETEROCYCLIC SULFONAMIDE INHIBITORS OF BETA AMYLOID PRODUCTION
- 专利标题（中）： β-淀粉酶生产的杂环磺酰胺抑制剂
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申请号： US12576513申请日： 2009-10-09
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公开(公告)号： US20100022594A1公开(公告)日： 2010-01-28
- 发明人: Anthony F. Kreft , Derek Cecil Cole , Kevin R. Woller , Joseph R. Stock , George Diamantidis , Dennis M. Kubrak , Kristina M. Kutterer , William J. Moore , David S. Casebier
- 申请人： Anthony F. Kreft , Derek Cecil Cole , Kevin R. Woller , Joseph R. Stock , George Diamantidis , Dennis M. Kubrak , Kristina M. Kutterer , William J. Moore , David S. Casebier
- 申请人地址： US NJ Madison US MA Woburn
- 专利权人： Wyeth,ArQule, Inc.
- 当前专利权人： Wyeth,ArQule, Inc.
- 当前专利权人地址： US NJ Madison US MA Woburn
- 主分类号： A61K31/381
- IPC分类号： A61K31/381 ; A61K31/4535 ; A61K31/382 ; A61K31/34 ; C07D409/12 ; C07D333/34 ; C07D307/64 ; A61P25/00
摘要：
Compounds of Formula (I), wherein R1, R2, R3, R4, R5, R6, T, W, X, Y and Z are as defined herein are provided, together with pharmaceutically acceptable salt, hydrates and/or prodrugs thereof. Methods of using these compounds for inhibiting beta amyloid production and for treatment of Alzheimer's disease and Down's syndrome are described.