发明申请
US20100022637A1 IDENTIFICATION OF ANTI-CANCER COMPOUNDS AND COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE AND METHODS OF TREATMENT THEREOF
审中-公开
用于治疗亨廷顿病的抗癌化合物和化合物的鉴定及其治疗方法
- 专利标题： IDENTIFICATION OF ANTI-CANCER COMPOUNDS AND COMPOUNDS FOR TREATING HUNTINGTON'S DISEASE AND METHODS OF TREATMENT THEREOF
- 专利标题（中）： 用于治疗亨廷顿病的抗癌化合物和化合物的鉴定及其治疗方法
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申请号： US11992867申请日： 2006-09-29
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公开(公告)号： US20100022637A1公开(公告)日： 2010-01-28
- 发明人: Brent R. Stockwell , Inese Smukste
- 申请人： Brent R. Stockwell , Inese Smukste
- 申请人地址： US NY New York
- 专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人： THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK
- 当前专利权人地址： US NY New York
- 国际申请： PCT/US2006/038132 WO 20060929
- 主分类号： A61K31/35
- IPC分类号： A61K31/35 ; C12N5/02 ; G01N33/00 ; A61K31/16 ; C07D315/00 ; A61P35/04 ; A61P25/28
摘要：
Small molecule screening via high-throughput screening (HTS) methods was employed to identify compounds useful for treating or preventing cancer (such as compounds that enable cells to overcome E6-oncoprotein-mediated drug resistance) or neurodegenerative disorders (such as Huntington's disease, HD). Compounds were identified that potentiate the lethality of anti-tumor agents as well as rescue a disease-state lethality. These compounds are acylated secondary amines referred to herein as indoxins and revertins.
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