发明申请
- 专利标题： PRODRUGS OF DIPHENYL OX-INDOL-2-ONE COMPOUNDS
- 专利标题（中）： 二苯氧基-2-二醇化合物的制备方法
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申请号： US12518545申请日： 2007-12-11
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公开(公告)号： US20100029646A1公开(公告)日： 2010-02-04
- 发明人: Mette Knak Christensen , Fredrik Bjoerkling , Martins Ikaunieks , Andrei Zaichenko , Vija Gailite , Einars Loza , Ivars Kalvinsh , Marina Madre
- 申请人： Mette Knak Christensen , Fredrik Bjoerkling , Martins Ikaunieks , Andrei Zaichenko , Vija Gailite , Einars Loza , Ivars Kalvinsh , Marina Madre
- 申请人地址： DK Copenhagen
- 专利权人： Topo Target A/S
- 当前专利权人： Topo Target A/S
- 当前专利权人地址： DK Copenhagen
- 国际申请： PCT/EP2007/010805 WO 20071211
- 主分类号： A61K31/404
- IPC分类号： A61K31/404 ; C07D209/34 ; C07D403/06 ; C07D413/06 ; A61P35/00 ; A61K31/496 ; A61K31/5377
摘要：
The present application discloses prodrugs of substituted 3,3-diphenyl-1,3-dihydro-indol-2-one compounds having the general formula (I). The 4-position of the phenyl moieties and the N-position of the indole represent useful handles for the introduction of particular prodrug groups, in particular those comprising an amino acid moiety. The prodrug compounds are believed to be useful for the treatment of cancer in a mammal, possibly in combination with one or more other chemotherapeutic agents. The application also discloses the compounds for use in a method of treating a mammal suffering from or being susceptible to cancer
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