发明申请
- 专利标题： 2-SUBSTITUTED PROLINE BIS-AMIDE OREXIN RECEPTOR ANTAGONISTS
- 专利标题（中）： 2-取代的双胺双磺酰胺受体拮抗剂
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申请号： US12302122申请日： 2007-07-13
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公开(公告)号： US20100029736A1公开(公告)日： 2010-02-04
- 发明人: Christopher D. Cox , David B. Whitman , Michael J. Breslin
- 申请人： Christopher D. Cox , David B. Whitman , Michael J. Breslin
- 申请人地址： US NJ Rahway
- 专利权人： MERCK & CO., INC.
- 当前专利权人： MERCK & CO., INC.
- 当前专利权人地址： US NJ Rahway
- 国际申请： PCT/US07/16125 WO 20070713
- 主分类号： A61K31/4184
- IPC分类号： A61K31/4184 ; C07D403/06 ; C07D403/12 ; A61P3/04
摘要：
The present invention is directed to 2-substituted proline bis-amide compounds which are antagonists of orexin receptors, and which are useful in the treatment or prevention of neurological and psychiatric disorders and diseases in which orexin receptors are involved. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which orexin receptors are involved.
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