发明申请
US20100029952A1 Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems
有权
氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用
- 专利标题： Fluorogenic compounds converted to fluorophores by photochemical or chemical means and their use in biological systems
- 专利标题（中）： 氟化合物通过光化学或化学方法转化为荧光团，并在生物系统中的应用
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申请号： US12454273申请日： 2009-05-13
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公开(公告)号： US20100029952A1公开(公告)日： 2010-02-04
- 发明人: Robert J. Tweg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
- 申请人： Robert J. Tweg , William E. Moerner , Samuel J. Lord , Na Liu , Reichel Samuel
- 申请人地址： US OH KENT US CA PALO ALTO
- 专利权人： KENT STATE UNIVERSITY,LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人： KENT STATE UNIVERSITY,LELAND STANFORD JUNIOR UNIVERSITY
- 当前专利权人地址： US OH KENT US CA PALO ALTO
- 主分类号： C07D213/02
- IPC分类号： C07D213/02 ; C07D307/02 ; C07D249/04 ; C07D271/12
摘要：
Fluorophores derived from photoactivatable azide-pi-acceptor fluorogens or from a thermal reaction of an azide-pi-acceptor fluorogen with an alkene or alkyne are disclosed. Fluorophores derived from a thermal reaction of an alkyne-pi-acceptor fluorogen with an azide are also disclosed. The fluorophores can readily be activated by light and can be used to label a biomolecule and imaged on a single-molecule level in living cells.