发明申请
- 专利标题: Amide Linkage Cyclic Natriuretic Peptide Constructs
- 专利标题(中): 酰胺连接循环利钠肽构建体
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申请号: US12572284申请日: 2009-10-02
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公开(公告)号: US20100035821A1公开(公告)日: 2010-02-11
- 发明人: Shubh D. Sharma , Margarita Bastos , Wei Yang
- 申请人: Shubh D. Sharma , Margarita Bastos , Wei Yang
- 申请人地址: US NJ Cranbury
- 专利权人: PALATIN TECHNOLOGIES, INC.
- 当前专利权人: PALATIN TECHNOLOGIES, INC.
- 当前专利权人地址: US NJ Cranbury
- 主分类号: A61K38/10
- IPC分类号: A61K38/10 ; C07K7/08 ; A61P9/10
摘要:
Cyclic constructs which bind to a natriuretic peptide receptor and include a plurality of amino acid residues, at least one amino acid surrogate of formula I: where R, R′, Q, Y, W, Z, J, x and n are as defined in the specification, and a cyclic linkage including one or two amide bonds, pharmaceutical compositions including such cyclic constructs, and methods of treating congestive heart failure or other conditions, syndromes or diseases for which induction of anti-hypertensive, cardiovascular, renal or endocrine effects are desired.
公开/授权文献
- US08580746B2 Amide linkage cyclic natriuretic peptide constructs 公开/授权日:2013-11-12