A cleaning device for scanner includes a handhold portion and a cleaning portion including a window cleaning surface. The handhold portion and the cleaning portion are fixed together, and the thickness of the handhold portion is larger than that of the cleaning portion. The cleaning portion further includes a loading body. The loading body can be a hard or flexible flat board that has a first end, which is fixed with the handhold portion, and a second end. The cleaning process of the cleaning device for the scanner is simple. The window cleaning surface can be replaceable or not and is cheap when manufactured, suitable for being used in any scanner having an immovable scanning module relative to its housing, and more practically, for cleaning the glass window and roller of small size and any portable scanner, so as to maintain scanning quality and scanning precision.