发明申请
US20100040575A1 USE OF INHIBITORS OF GLUTAMINYL CYCLASE AND GLUTAMATE CYCLASE FOR TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES
有权
谷氨酰胺环糊精和谷氨酸环化酶抑制剂用于治疗和预防神经病变性疾病的使用
- 专利标题： USE OF INHIBITORS OF GLUTAMINYL CYCLASE AND GLUTAMATE CYCLASE FOR TREATMENT AND PREVENTION OF NEURODEGENERATIVE DISEASES
- 专利标题（中）： 谷氨酰胺环糊精和谷氨酸环化酶抑制剂用于治疗和预防神经病变性疾病的使用
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申请号： US12506823申请日： 2009-07-21
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公开(公告)号： US20100040575A1公开(公告)日： 2010-02-18
- 发明人: Torsten Hoffmann , Stephan Schilling , Andre J. Niestroj , Hans-Ulrich Demuth , Ulrich Heiser , Mirko Buchholz
- 申请人： Torsten Hoffmann , Stephan Schilling , Andre J. Niestroj , Hans-Ulrich Demuth , Ulrich Heiser , Mirko Buchholz
- 申请人地址： DE Halle/Saale
- 专利权人： PROBIODRUG AG
- 当前专利权人： PROBIODRUG AG
- 当前专利权人地址： DE Halle/Saale
- 主分类号： A61K31/4164
- IPC分类号： A61K31/4164 ; A61P25/00 ; A61P25/28 ; A61K31/4184 ; A61K31/428 ; A61K31/517 ; A61K31/5415 ; A61K39/395 ; A61K38/21 ; A61K45/00
摘要：
Physiological substrates of mammalian glutaminyl cyclase (QC, EC 2.3.2.5), new effectors of QC, methods for screening for such effectors, and the use of such effectors and pharmaceutical compositions comprising such effectors for the treatment of conditions that can be treated by modulation of QC-activity. Preferred compositions additionally comprise inhibitors of DP IV or DP IV-like enzymes for the treatment or alleviation of conditions that can be treated by modulation of QC- and DP IV-activity.
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