发明申请
- 专利标题: Antibodies to c-Met
- 专利标题(中): c-Met的抗体
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申请号: US12321963申请日: 2009-01-26
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公开(公告)号: US20100040629A1公开(公告)日: 2010-02-18
- 发明人: Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
- 申请人: Neil R. Michaud , Shama Kajiji , Gary Borzillo , Vahe Bedian , Kevin Coleman , Larry L. Green , Xiao-Chi Jia
- 申请人地址: US CA Fremont US NY New York
- 专利权人: Abgenix, Inc.,Pfizer, Inc.
- 当前专利权人: Abgenix, Inc.,Pfizer, Inc.
- 当前专利权人地址: US CA Fremont US NY New York
- 主分类号: A61K39/395
- IPC分类号: A61K39/395
摘要:
The present invention relates to antibodies including human antibodies and antigen-binding portions thereof that specifically bind to c-Met, preferably human c-Met, and that function to inhibit c-Met. The invention also relates to human anti-c-Met antibodies and antigen-binding portions thereof. The invention also relates to antibodies that are chimeric, bispecific, derivatized, single chain antibodies or portions of fusion proteins. The invention also relates to isolated heavy and light chain immunoglobulins derived from human anti-c-Met antibodies and nucleic acid molecules encoding such immunoglobulins. The present invention also relates to methods of making human anti-c-Met antibodies, compositions comprising these antibodies and methods of using the antibodies and compositions for diagnosis and treatment. The invention also provides gene therapy methods using nucleic acid molecules encoding the heavy and/or light immunoglobulin molecules that comprise the human anti-c-Met antibodies. The invention also relates to transgenic animals or plants comprising nucleic acid molecules of the present invention.
公开/授权文献
- US08163280B2 Antibodies to c-Met 公开/授权日:2012-04-24
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