发明申请
US20100041708A1 N-PHENYLARYLSULFONAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUND AS ACTIVE INGREDIENT, SYNTHETIC INTERMEDIATE FOR THE COMPOUND AND PROCESS FOR IT'S PREPARATION
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N-苯基磺酰胺化合物,包含该化合物作为活性成分的药物组合物,该化合物的合成中间体及其制备方法
- 专利标题: N-PHENYLARYLSULFONAMIDE COMPOUND, PHARMACEUTICAL COMPOSITION COMPRISING THE COMPOUND AS ACTIVE INGREDIENT, SYNTHETIC INTERMEDIATE FOR THE COMPOUND AND PROCESS FOR IT'S PREPARATION
- 专利标题(中): N-苯基磺酰胺化合物,包含该化合物作为活性成分的药物组合物,该化合物的合成中间体及其制备方法
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申请号: US12603194申请日: 2009-10-21
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公开(公告)号: US20100041708A1公开(公告)日: 2010-02-18
- 发明人: Atsushi NAGANAWA , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
- 申请人: Atsushi NAGANAWA , Tetsuji Saito , Kaoru Kobayashi , Takayuki Maruyama , Yoshihiko Nakai , Shinsuke Hashimoto
- 申请人地址: JP Mishima-gun
- 专利权人: ONO PHARMACEUTICAL Co., Ltd.
- 当前专利权人: ONO PHARMACEUTICAL Co., Ltd.
- 当前专利权人地址: JP Mishima-gun
- 优先权: JP2001-68498 20010312; JP2001-281569 20010917; JP2002-7760 20020116
- 主分类号: A61K31/18
- IPC分类号: A61K31/18 ; C07D307/64 ; C07D277/36 ; C07D213/70 ; C07D401/12 ; A61K31/341 ; A61K31/426 ; A61K31/4406 ; A61K31/4439 ; A61P13/00
摘要:
An N-phenylarylsulfonylamide compound of formula (I) (R1 is COOH etc.; R2 is hydrogen, methyl, etc.; R3 and R4 are a combination of methyl and methyl, etc.; R5 is isopropyl etc.; Ar is thiazolyl, pyridyl, 5-methyl-2-furyl each optionally substituted with methyl; n is zero or 1), a synthetic intermediate for the compound and a process for its preparation. The compound of formula (I) binds to a prostaglandin E2 receptor, especially an EP1 subtype receptor, and antagonizes it. It is less affected by protein binding, so it has a satisfactory in vivo activity. Therefore, it is considered to be useful as an analgesic, an antipyretic agent, an agent for the treatment of pollakiuria (frequent urination) and/or lower urinary tract disease syndrome or an antineoplastic agent.